A minimal gene set for cellular life derived by comparison of complete bacterial genomes.
نویسندگان
چکیده
منابع مشابه
Determination of the core of a minimal bacterial gene set.
The availability of a large number of complete genome sequences raises the question of how many genes are essential for cellular life. Trying to reconstruct the core of the protein-coding gene set for a hypothetical minimal bacterial cell, we have performed a computational comparative analysis of eight bacterial genomes. Six of the analyzed genomes are very small due to a dramatic genome size r...
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In this study, we adapt a protocol for the growth of previously uncultured environmental bacterial isolates, to make it compatible with whole genome sequencing. We demonstrate that in combination with the MinION sequencing device, complete assemblies can be derived, allowing genomic comparisons to be made. This approach allows rapid, inexpensive and straightforward discovery, and genomic analys...
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74 Tools for Comparison of Bacterial Genomes
Of the plethora of bioinformatical tools available, some useful tools that allow complete genome sequences to be compared are described here. Comparisons of genome length, base composition, gene density, numbers of tRNA and rRNA genes, and codon usage can provide useful biological insights. Examples are provided of a Genome Atlas plot, to summarize many features of a single genome, and a BLAST ...
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Mobile genetic elements can be found in almost all genomes. Possibly the most common nonautonomous mobile genetic elements in bacteria are repetitive extragenic palindromic doublets forming hairpins (REPINs) that can occur hundreds of times within a genome. The sum of all REPINs in a genome can be viewed as an evolving population because REPINs replicate and mutate. In contrast to most other bi...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1996
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.93.19.10268